Nepheli was married to King Athamanta, who later was married to Ino. His children from the first marriage, Frixos and Elli, were scorned by Ino, who wanted to see her own sons on the throne, Klearhos and Melikerti. Through intrigues and irreal oracles, Frixos was commanded to be sacrificed, but the last moment Nepheli sent a wingy gold ram, which saved her two children and took them away flying over the sea.

Elli fell in the Ellispontos sea, while Frixos got to Kolhida, where he gifted the Golden Fleece to King Eiti and got married to his daughter, Halkiopi.